NMN: A Promising Solution to Enhance Immunotherapy and Extend Life Expectancy

NMN: A Promising Solution to Enhance Immunotherapy and Extend Life Expectancy

Table of Content:

Introduction to NMN and Its Impact on Immunotherapy

Nicotinamide Mononucleotide (NMN) is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital molecule involved in cellular energy production. Recent studies have demonstrated NMN's potential in enhancing immunotherapy's effects, particularly by increasing the efficiency of natural killer (NK) cells. In this article, we will explore the role of NMN in prolonging survival, suppressing tumour growth, and its potential implications in cancer therapy.

The Power of NMN-Treated NK Cells: Extended Survival and Tumor Suppression

Boosting the Lifespan of Mice with Cancer

A groundbreaking study conducted by researchers at Shandong University has revealed that NMN treatment can enhance the anti-tumour capabilities of NK cells, leading to significantly increased survival rates in mice with cancer. The study demonstrated that mice with liver cancer experienced a nearly threefold increase in lifespan when treated with NMN-boosted NK cells. This effect was also observed in mice with skin cancer, where NMN-treated NK cells effectively reduced tumour growth.

Amplifying NK Cell Tumor Suppression

The researchers discovered that when NK cells are treated with NMN, their ability to suppress liver tumour growth is considerably enhanced. This increase in efficiency is due to elevated NAD+ levels, which facilitate increased cellular energy production. With ample energy, NK cells can more effectively eliminate tumour cells and prevent further growth.

In the case of skin cancer, mice treated with NMN-enhanced NK cells experienced a significant reduction in tumour size compared to those treated with untreated NK cells. These findings indicate that NMN treatment can effectively boost NK cell performance in suppressing tumour growth across different types of cancer.

NMN’s Role in Immunotherapy: A Key to Unlocking Advanced Cancer Treatments

The Future of Cancer Therapy: Immunotherapy vs. Chemotherapy

Immunotherapy, which involves stimulating the immune system to combat cancer, is an emerging alternative to traditional chemotherapy. While chemotherapy relies on chemicals to attack cancer cells, immunotherapy leverages the body’s immune system to target and eliminate cancerous cells. With the demonstrated effectiveness of NMN treatment in enhancing NK cell function, there is real potential for NMN to play a crucial role in advancing immunotherapy as a more effective and less invasive cancer treatment option.

Potential Applications Beyond Cancer Treatment

In addition to its potential in cancer therapy, NMN treatment may have broader implications in the field of ageing and age-related diseases. Research has shown that NMN-enhanced NK cells can target senescent cells, accumulating with age and contributing to various age-related diseases. By eliminating these senescent cells, NMN treatment could slow the ageing process and help prevent the onset of age-related conditions.


The groundbreaking findings from preclinical studies on NMN treatment hold immense promise for the future of cancer therapy and ageing research. By enhancing the anti-tumour capabilities of NK cells and prolonging survival rates in mice with cancer, NMN shows potential as a key component in advancing immunotherapy as an alternative to chemotherapy. Furthermore, its potential role in targeting senescent cells and slowing down the ageing process opens up new possibilities for preventing and treating age-related diseases. While additional research, including human clinical trials and further investigation into the molecular mechanisms underlying NMN’s effects, is necessary, these initial findings offer hope for developing more effective and less invasive treatments in the battle against cancer and ageing.

Frequently Asked Questions

What is the significance of NMN treatment in cancer therapy?

NMN treatment has been shown to enhance the anti-tumour capabilities of NK cells, leading to prolonged survival rates in mice with cancer and more effective suppression of tumour growth. This suggests that NMN could be crucial in improving immunotherapy as a cancer treatment option.

How does NMN treatment affect the ageing process?

Research indicates that NMN-enhanced NK cells can target and eliminate senescent cells, which accumulate with age and contribute to various age-related diseases. By targeting these cells, NMN treatment may slow the ageing process and help prevent age-related conditions.

Are there any human clinical trials on NMN treatment for cancer therapy or ageing?

While the findings discussed in this article are based on preclinical studies involving mice, further research, including human clinical trials, is needed to confirm the efficacy of NMN treatment in humans and explore its potential applications in cancer therapy and ageing.

How does immunotherapy compare to chemotherapy as a cancer treatment option?

Immunotherapy is an emerging alternative to chemotherapy. Instead of using chemicals to attack cancer cells, immunotherapy stimulates the immune system to target and eliminate cancerous cells. NMN treatment can potentially improve immunotherapy's effectiveness, making it a promising option for future cancer treatments.

What are the next steps for NMN research in cancer therapy and ageing?

The next steps in NMN research include conducting human clinical trials to confirm its efficacy in cancer therapy and ageing and further investigating the molecular mechanisms underlying NMN’s effects on NK cells and tumour suppression. This will help develop practical applications for NMN treatment in cancer therapy and explore its potential role in slowing the ageing process.

Study Source 

Guo X, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z, Yan L, Yue X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T, Liang X. NAD+ salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity. Hepatology. 2022 Jul 11. doi: 10.1002/hep.32658. Epub ahead of print. PMID: 35815363.

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